Transformation-defective mutants with 5' deletions of the src gene are frequently generated during replication of Rous sarcoma virus in established quail fibroblasts.

doi:10.1016/0042-6822(90)90515-s

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Article

Transformation-defective mutants with 5' deletions of the src gene are frequently generated during replication of Rous sarcoma virus in established quail fibroblasts.

Virology - 1 Aug 1990

Barnier J V, Marx M, Dezelee P, Laugier D, Poirier F, Calothy G, Hillova J, Hill M

Abstract excerpt

Replication of Rous sarcoma virus (RSV) in avian fibroblasts leads to the generation of replication-competent variants that are defective for cell transformation (td virus). These td variants contain deletions affecting various portions of the v-src gene. We compared the rate of td virus producti...

Topics

Animals
Avian Sarcoma Viruses
Base Sequence
Cell Transformation, Viral
Cells, Cultured
Chromosome Deletion
Coturnix
DNA, Viral
Embryo, Nonmammalian
Molecular Sequence Data
Mutation
Oncogene Protein pp60(v-src)
Oncogenes
Restriction Mapping
Single-Strand Specific DNA and RNA Endonucleases

Source

Open in PubMed

Identifiers

PMID: 2164723
DOI: 10.1016/0042-6822(90)90515-s

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2164723-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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