Article
Induction of proliferation or transformation of neuroretina cells by the mil and myc viral oncogenes.
Nature - 1 Jan 2000
Bechade C, Calothy G, Pessac B, Martin P, Coll J, Denhez F, Saule S, Ghysdael J, Stéhelin D
Abstract excerpt
The genome of the avian retrovirus MH2 contains, in addition to the v-myc oncogene shared with three other avian retroviruses (MC29, CMII and OK-10), a second cell-derived oncogene, v-mil (refs 1-3). Like the three other viruses, which contain only v-myc, MH2 induces mainly liver and kidney carcinomas in fowl and transforms fibroblasts and macrophages in vitro. However, MH2 and MC29 differ in their biological...
Topics
- Animals
- Avian Leukosis Virus
- Cell Division
- Cell Transformation, Viral
- Cells, Cultured
- Chick Embryo
- Genes, Viral
- Mutation
- Neurons
- Oncogenes
- RNA, Viral