Article
SV40 recombinants carrying a d(CT.GA)22 sequence show increased genomic instability.
Gene - 15 Dec 1991
Bernúes J, Beltrán R, Azorín F
Abstract excerpt
Repetitive d(CT.GA)n sequences are commonly found in eukaryotic genomic DNA. They are frequently located in sites involved in genetic recombination or in promoter regions. To test for their possible biological function, a d(CT.GA)22 synthetic sequence was introduced into the genome of SV40, since it constitutes an appropriate model system for eukaryotic chromatin. When SV40 infects permissive cells, it...
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