Article
Retroviral capture of c-erbB proto-oncogene sequences: rapid evolution of distinct viral genomes carrying mutant v-erbB genes with different transforming capacities.
Oncogene - 1 May 1994
Vennström B, Raynoscheck C, Jansson L, Doederlein G, Lhotak V, Johnsson A, Beug H
Abstract excerpt
The evolution of oncogene-transducing retroviruses was followed by studying the genomes of five new, erbB carrying retroviruses. These viruses, isolated from cells of one chicken infected with Rous Associated virus 1 (RAV-1), had captured c-erbB sequences as a consequence of RAV-1 integration into the host genome. Their genome structures were distinct; however, their v-erbB genes had sustained identical 5' and 3'...
Topics
- Amino Acid Sequence
- Animals
- Avian Leukosis Virus
- Base Sequence
- Cell Transformation, Viral
- Chick Embryo
- Chickens
- ErbB Receptors
- Gene Deletion
- Gene Rearrangement
- Genes, gag