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Article

A synthetic A tail rescues yeast nuclear accumulation of a ribozyme-terminated transcript.

RNA (New York, N.Y.) - 1 Dec 2004

Dower Ken, Kuperwasser Nicolas, Merrikh Houra, Rosbash Michael

Abstract excerpt

To investigate the role of 3' end formation in yeast mRNA export, we replaced the mRNA cleavage and polyadenylation signal with a self-cleaving hammerhead ribozyme element. The resulting RNA is unadenylated and accumulates near its site of synthesis. Nonetheless, a significant fraction of this RNA reaches the cytoplasm. Nuclear accumulation was relieved by insertion of a stretch of DNA-encoded adenosine residues...

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Identifiers

PMID: 15547135
DOI: 10.1261/rna.7166704
PMCID: PMC1370677

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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