Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutational analysis of Cak1p, an essential protein kinase that regulates cell cycle progression.

Molecular & general genetics : MGG - 1 Oct 1997

Chun K T, Goebl M G

Abstract excerpt

In Saccharomyces cerevisiae, entry into S phase requires the activation of the protein kinase Cdc28p through binding with cyclin Clb5p or Clb6p, as well as the destruction of the cyclin-dependent kinase inhibitor Sic1p. Mutants that are defective in this activation event arrest after START, with unreplicated DNA and multiple, elongated buds. These mutants include cells defective in CDC4, CDC34 or CDC53, as well...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Cell Cycle
Share to DNA Mutational Analysis

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Molecular Sequence Data

Share to Phenotype

Share to Rabbits

Share to Recombinant Fusion Proteins

Share to Saccharomyces cerevisiae

Source

Identifiers

PMID: 9393434
DOI: 10.1007/s004380050580

Genes

CDC34

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutational analysis of Cak1p, an essential protein kinase that regulates cell cycle progression.PMID 9393434Read ↗

The Cak1p protein kinase is required at G1/S and G2/M in the budding yeast cell cycle.Semantic proximity Read ↗

Cak1 is required for Kin28 phosphorylation and activation in vivo.Semantic proximity Read ↗

The Cdk-associated protein Cks1 functions both in G1 and G2 in Saccharomyces cerevisiae.Semantic proximity Read ↗

The role of CDC28 and cyclins during mitosis in the budding yeast S. cerevisiae.Semantic proximity Read ↗

A phosphorylation-independent role for the yeast cyclin-dependent kinase activating kinase Cak1.Semantic proximity Read ↗

Cks1 is dispensable for survival in Saccharomyces cerevisiae.Semantic proximity Read ↗

Identification of YPL014W (Cip1) as a novel negative regulator of cyclin-dependent kinase in Saccharomyces cerevisiae.Semantic proximity Read ↗

Functional distinction between Cln1p and Cln2p cyclins in the control of the Saccharomyces cerevisiae mitotic cycle.Semantic proximity Read ↗

Negative regulation of G1 and G2 by S-phase cyclins of Saccharomyces cerevisiae.Semantic proximity Read ↗

The Cdk-activating kinase Cak1p promotes meiotic S phase through Ime2p.Semantic proximity Read ↗

Fission yeast Clp1p phosphatase affects G2/M transition and mitotic exit through Cdc25p inactivation.Semantic proximity Read ↗

The identification of Pcl1-interacting proteins that genetically interact with Cla4 may indicate a link between G1 progression and mitotic exit.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.