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Article

A phosphorylation-independent role for the yeast cyclin-dependent kinase activating kinase Cak1.

Gene - 15 Nov 2009

Kim Su-Hwa, Gadiparthi Keerthi, Kron Stephen J, Kitazono Ana A

Abstract excerpt

Cdc28 is the main cyclin-dependent kinase (CDK) directing the cell cycle in the budding yeast Saccharomyces cerevisiae. Besides cyclin binding, Cdc28 requires phosphorylation by the Cak1 kinase to achieve full activity. We have previously isolated carboxy-terminal cdc28(CST) mutants that are temperature sensitive and exhibit high chromosome instability. Both phenotypes are suppressed by high copy Cak1 in a manner...

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Identifiers

PMID: 19647054
DOI: 10.1016/j.gene.2009.07.016
PMCID: PMC4562314

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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