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Article

Differential and cooperative polysialylation of the neural cell adhesion molecule by two polysialyltransferases, PST and STX.

The Journal of biological chemistry - 23 Oct 1998

Angata K, Suzuki M, Fukuda M

Abstract excerpt

PST and STX are polysialyltransferases that form polysialic acid in the neural cell adhesion molecule (NCAM), and these two polysialyltransferases often exist together in the same tissues. To determine the individual and combined roles of PST and STX in polysialic acid synthesis, in the present study we asked if PST and STX differ in the acceptor requirement and if PST and STX act together in polysialylation of...

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PMID: 9774483
DOI: 10.1074/jbc.273.43.28524

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Differential and cooperative polysialylation of the neural cell adhesion molecule by two polysialyltransferases, PST and STX.PMID 9774483Read ↗

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The polysialyltransferases interact with sequences in two domains of the neural cell adhesion molecule to allow its polysialylation.Semantic proximity Read ↗

Polysialyltransferase-1 autopolysialylation is not requisite for polysialylation of neural cell adhesion molecule.Semantic proximity Read ↗

Specific amino acids in the first fibronectin type III repeat of the neural cell adhesion molecule play a role in its recognition and polysialylation by the polysialyltransferase ST8Sia IV/PST.Semantic proximity Read ↗

The impact of N-glycosylation on the functions of polysialyltransferases.Semantic proximity Read ↗

Different properties of polysialic acids synthesized by the polysialyltransferases ST8SIA2 and ST8SIA4.Semantic proximity Read ↗

Polysialic acid directs tumor cell growth by controlling heterophilic neural cell adhesion molecule interactions.Semantic proximity Read ↗

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Polysialic acid profiles of mice expressing variant allelic combinations of the polysialyltransferases ST8SiaII and ST8SiaIV.Semantic proximity Read ↗

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