Article
G protein beta3 subunit gene 825T allele is associated with increased left ventricular mass in young subjects with mild hypertension.
American journal of hypertension - 1 Dec 2001
Semplicini A, Siffert W, Sartori M, Monari A, Naber C, Frigo G, Santonastaso M, Cozzutti E, Winnicki M, Palatini P
Abstract excerpt
BACKGROUND: A nucleotide substitution (C-->T) at position 825 of the gene GNB3 encoding the beta3 subunit of heterotrimeric G proteins is associated with alternative splicing and enhanced signal transduction. There is accumulating evidence from different populations that the 825T allele is associated with increased prevalence of hypertension, obesity, and left ventricular hypertrophy. However, it is unclear to...
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