Association of a polymorphism of the angiotensin I-converting enzyme gene with essential hypertension.

doi:10.1016/0006-291x(92)91150-o

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Article

Association of a polymorphism of the angiotensin I-converting enzyme gene with essential hypertension.

Biochemical and biophysical research communications - 15 Apr 1992

Zee R Y, Lou Y K, Griffiths L R, Morris B J

Abstract excerpt

Angiotensin I-converting enzyme (ACE) is responsible for production of angiotensin II and breakdown of kinins, leading to increased blood pressure (BP). Furthermore, ACE inhibitors are effective antihypertensive agents. A 287 bp insertion/deletion polymorphism in intron 16 of the ACE gene (ACE) was examined by PCR in a cross-sectional study of 80 hypertensive (HT) and 93 normotensive (NT) subjects whose parents...

Topics

Adult
Aged
Alleles
Base Sequence
Blood Pressure
Chromosome Deletion
DNA
DNA Transposable Elements
Genotype
Humans
Hypertension
Introns

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Leukocytes

Molecular Sequence Data

Oligodeoxyribonucleotides

Oligonucleotides, Antisense

Peptidyl-Dipeptidase A

Polymerase Chain Reaction

Source

Open in PubMed

Identifiers

PMID: 1314601
DOI: 10.1016/0006-291x(92)91150-o

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Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1314601-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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