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Article

TIMP-2 modulates cancer cell transcriptional profile and enhances E-cadherin/beta-catenin complex expression in A549 lung cancer cells.

Oncotarget - 1 Jan 2013

Bourboulia Dimitra, Han HuiYing, Jensen-Taubman Sandra, Gavil Noah, Isaac Biju, Wei Beiyang, Neckers Len, Stetler-Stevenson William G

Abstract excerpt

Tissue Inhibitor of Metalloproteinase 2 (TIMP-2) plays an essential role in regulating matrix remodeling, cell growth, differentiation, angiogenesis and apoptosis in vitro and in vivo. We have recently shown that TIMP-2-mediated inhibition of tumor growth is independent of matrix metalloproteinase-mediated mechanisms, and is a consequence of modulating both the tumor cells and the tumor microenvironment. In the...

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Identifiers

PMID: 23371049
DOI: 10.18632/oncotarget.801
PMCID: PMC3702216

Genes

EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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TIMP-2 modulates cancer cell transcriptional profile and enhances E-cadherin/beta-catenin complex expression in A549 lung cancer cells.PMID 23371049Read ↗

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