Article
[Inhibitory effects of siRNA targeting epidermal growth factor receptor on proliferation and invasion of human glioblastoma cells].
Zhonghua yi xue za zhi - 17 Sept 2004
Kang Chun-Sheng, Pu Pei-Yu, Wang Guang-Xiu, Li Yan-He, Dong Lun, Wang Hu
Abstract excerpt
OBJECTIVE: To study the inhibitory effects of siRNA targeting epidermal growth factor receptor (EGFR) on the proliferation and invasion of human glioblastoma cells. METHOD: Two siRNA expression constructs using psiRNA-NeoG2 vector, that targeted sequences of human EGFR receptor L domain (516 - 536) and catalytic domain (2400 - 2420) respectively, were constructed. Human malignant glioma cells of the line TJ905...
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