Article
p53--an acrobat in tumorigenesis.
Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists - 1 Jan 1998
Moll U M, Schramm L M
Abstract excerpt
The p53 tumor suppressor protein plays a central role in maintaining genomic integrity. It does so by occupying a nodal point in the DNA damage control pathway. When cells are subject to ionizing radiation or other mutagenic events, p53 mediates cell cycle arrest or programmed cell death (apoptosis). Furthermore, some evidence suggests that p53 plays a role in the recognition and repair of damaged DNA....
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