Article
Dihydroorotate (dhout) and orotate (orout) utilizer mutants in yeast: identification of the dhout mutation and allelism of the DHO and URE2 genes.
Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie - 1 Apr 1998
Bloch J C, Pfeiffer P, Exinger F
Abstract excerpt
We induced by UV mutagenesis a series of yeast mutants that were able to utilize dihydroorotic (dhout) and orotic acid (orout) as precursors for pyrimidine biosynthesis. These recessive mutations defined three complementation groups named dhout, orout1 and orout2. The wild-type allele of the gene responsible for dihydroorotate utilization was cloned using the sensitivity of the dhout mutant to 5-fluoroorotate....
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