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Article

Over-production of dihydrofolate reductase leads to sulfa-dihydropteroate resistance in yeast.

FEMS microbiology letters - 15 Jul 2004

Patel Onisha, Karnik Kuldeep, Macreadie Ian G

Abstract excerpt

Dihydropteroate synthase (DHPS) can metabolise sulfa drugs into sulfa-dihydropteroate (sulfa-DHP), which inhibits cell growth through competition with dihydrofolate (DHF), possibly indicating dihydrofolate reductase (DHFR) as the target of sulfa-DHP. The effect of over-production of DHFR on sulfa-DHP resistance was examined in Saccharomyces cerevisiae using a strain that requires DHF for growth. This strain was...

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Source

Identifiers

PMID: 15251211
DOI: 10.1016/j.femsle.2004.06.001

Genes

DHFR
DHPS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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