Article
A mutated ARO4 gene for feedback-resistant DAHP synthase which causes both o-fluoro-DL-phenylalanine resistance and beta-phenethyl-alcohol overproduction in Saccharomyces cerevisiae.
Current genetics - 1 Dec 1991
Fukuda K, Watanabe M, Asano K, Ouchi K, Takasawa S
Abstract excerpt
o-Fluoro-DL-phenylalanine (OFP)-resistant mutants which overproduce beta-phenethyl-alcohol were isolated from a laboratory strain of Saccharomyces cerevisiae. Cells of one of the mutants accumulated tyrosine and phenylalanine 1.5-3 fold more than did wild-type cells. Its 3-deoxy-D-arabino-hepturo...
Topics
- 3-Deoxy-7-Phosphoheptulonate Synthase
- Base Sequence
- Cloning, Molecular
- DNA, Fungal
- Drug Resistance, Microbial
- Feedback
- Gene Expression Regulation, Fungal
- Genes, Dominant
- Genes, Fungal
- Molecular Sequence Data
- Mutation
- Phenylalanine
- Phenylethyl Alcohol
- Saccharomyces cerevisiae
- Transformation, Genetic