Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

5-Fluoro-orotic acid induces chromosome alterations in Candida albicans.

Yeast (Chichester, England) - 15 Jan 2005

Wellington Melanie, Rustchenko Elena

Abstract excerpt

Treatment of a prototrophic laboratory strain of Candida albicans with 5-fluoro-orotic acid (5-FOA) produced two major types of mutants with chromosomal alterations, 5-FOA-resistant (FoaR) and those remaining sensitive (FoaS). Both major types remained Ura+. FoaR mutants, produced after a long exposure, contained either a duplication of chromosome 4b or an inner enlargement of chromosome 5b. The average mutant...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Candida albicans
Share to Chromosome Aberrations
Share to Chromosomes, Fungal

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Karyotyping

Share to Mutation

Share to Orotic Acid

Share to Phenotype

Source

Identifiers

PMID: 15635674
DOI: 10.1002/yea.1191

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

5-Fluoro-orotic acid induces chromosome alterations in Candida albicans.PMID 15635674Read ↗

5-fluoro-orotic acid induces chromosome alterations in genetically manipulated strains of Candida albicans.Semantic proximity Read ↗

Aneuploid Chromosomes Are Highly Unstable during DNA Transformation of Candida albicansSemantic proximity Read ↗

Acquisition of Aneuploidy Provides Increased Fitness during the Evolution of Antifungal Drug ResistanceSemantic proximity Read ↗

Isolation, characterization, and genetic analysis of monosomic, aneuploid mutants of Candida albicans.Semantic proximity Read ↗

Moderate levels of 5-fluorocytosine cause the emergence of high frequency resistance in cryptococci.Semantic proximity Read ↗

Aneuploidy and Isochromosome Formation in Drug-Resistant <i>Candida albicans</i>Semantic proximity Read ↗

Variations of Candida albicans electrophoretic karyotypes.Semantic proximity Read ↗

Genetic prerequisites for additive or synergistic actions of 5-fluorocytosine and fluconazole in baker's yeast.Semantic proximity Read ↗

<i>URA6</i> mutations provide an alternative mechanism for 5-FOA resistance in <i>Saccharomyces cerevisiae</i>Semantic proximity Read ↗

An evaluation of the role of LIG4 in genomic instability and adaptive mutagenesis in Candida albicans.Semantic proximity Read ↗

Loss and fragmentation of chromosome 5 are major events linked to the adaptation of rad52-DeltaDelta strains of Candida albicans to sorbose.Semantic proximity Read ↗

Specific chromosome alterations in fluconazole-resistant mutants of Candida albicans.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.