Utilization of orotate as a pyrimidine source by Salmonella typhimurium and Escherichia coli requires the dicarboxylate transport protein encoded by dctA.

doi:10.1128/jb.178.24.7099-7105.1996

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Article

Utilization of orotate as a pyrimidine source by Salmonella typhimurium and Escherichia coli requires the dicarboxylate transport protein encoded by dctA.

Journal of bacteriology - 1 Dec 1996

Baker K E, Ditullio K P, Neuhard J, Kelln R A

Abstract excerpt

Mutants deficient in orotate utilization (initially termed out mutants) were isolated by selection for resistance to 5-fluoroorotate (FOA), and the mutations of 12 independently obtained isolates were found to map at 79 to 80 min on the Salmonella typhimurium chromosome. A gene complementing the...

Topics

Amino Acid Sequence
Bacterial Proteins
Base Sequence
Carrier Proteins
Chromosome Mapping
Cloning, Molecular
Culture Media
DNA, Bacterial
Dicarboxylic Acid Transporters
Dicarboxylic Acids
Escherichia coli
Gene Deletion
Molecular Sequence Data
Orotic Acid
Peptide Chain Initiation, Translational

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Identifiers

PMID: 8955389
DOI: 10.1128/jb.178.24.7099-7105.1996
PMCID: PMC178620

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8955389-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Phenotype

Pyrimidines

Salmonella typhimurium