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Article

Utilization of orotate as a pyrimidine source by Salmonella typhimurium and Escherichia coli requires the dicarboxylate transport protein encoded by dctA.

Journal of bacteriology - 1 Dec 1996

Baker K E, Ditullio K P, Neuhard J, Kelln R A

Abstract excerpt

Mutants deficient in orotate utilization (initially termed out mutants) were isolated by selection for resistance to 5-fluoroorotate (FOA), and the mutations of 12 independently obtained isolates were found to map at 79 to 80 min on the Salmonella typhimurium chromosome. A gene complementing the mutations was cloned and sequenced and found to possess extensive sequence identity to characterized genes for...

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Identifiers

PMID: 8955389
DOI: 10.1128/jb.178.24.7099-7105.1996
PMCID: PMC178620

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