Virion incorporation of human immunodeficiency virus type 1 Nef is mediated by a bipartite membrane-targeting signal: analysis of its role in enhancement of viral infectivity.

doi:10.1128/JVI.72.11.8833-8840.1998

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Article

Virion incorporation of human immunodeficiency virus type 1 Nef is mediated by a bipartite membrane-targeting signal: analysis of its role in enhancement of viral infectivity.

Journal of virology - 1 Nov 1998

Welker R, Harris M, Cardel B, Kräusslich H G

Abstract excerpt

The nef gene of primate immunodeficiency viruses is essential for high-titer virus replication and AIDS pathogenesis in vivo. In tissue culture, Nef is not required for human immunodeficiency virus (HIV) infection but enhances viral infectivity. We and others have shown that Nef is incorporated i...

Topics

Amino Acid Sequence
Animals
Base Sequence
COS Cells
Cell Membrane
Gene Products, nef
Genes, nef
Green Fluorescent Proteins
HIV-1
HeLa Cells
Humans
Luminescent Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutation

Phenotype

Plasmids

Recombinant Fusion Proteins

Signal Transduction

Source

Open in PubMed Open full text

Identifiers

PMID: 9765428
DOI: 10.1128/JVI.72.11.8833-8840.1998
PMCID: PMC110300

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9765428-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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