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Article

Optimal infectivity in vitro of human immunodeficiency virus type 1 requires an intact nef gene.

Journal of virology - 1 May 1994

Chowers M Y, Spina C A, Kwoh T J, Fitch N J, Richman D D, Guatelli J C

Abstract excerpt

The replication competence of human immunodeficiency virus type 1 genomes containing mutations in the nef open reading frame was evaluated in continuous cell lines. Mutants that contained a deletion in the nef open reading frame, premature termination codons, or missense mutations in the N-terminal myristoylation signal were constructed. The replication of these mutants was tested in three ways. First, plasmid...

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Identifiers

PMID: 8151761
DOI: 10.1128/JVI.68.5.2906-2914.1994
PMCID: PMC236779

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Related research

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Optimal infectivity in vitro of human immunodeficiency virus type 1 requires an intact nef gene.PMID 8151761Read ↗

Producer-cell modification of human immunodeficiency virus type 1: Nef is a virion protein.Semantic proximity Read ↗

Human immunodeficiency virus type 1 Nef increases the efficiency of reverse transcription in the infected cellSemantic proximity Read ↗

Expression of the human immunodeficiency virus type 1 (HIV-1) nef gene during HIV-1 production increases progeny particle infectivity independently of gp160 or viral entrySemantic proximity Read ↗

Nef-Mediated Downregulation of CD4 Enhances Human Immunodeficiency Virus Type 1 Replication in Primary T LymphocytesSemantic proximity Read ↗

The importance of nef in the induction of human immunodeficiency virus type 1 replication from primary quiescent CD4 lymphocytes.Semantic proximity Read ↗

Establishment of a MAGI-derived indicator cell line that detects the Nef enhancement of HIV-1 infectivity with high sensitivity.Semantic proximity Read ↗

Virion incorporation of human immunodeficiency virus type 1 Nef is mediated by a bipartite membrane-targeting signal: analysis of its role in enhancement of viral infectivity.Semantic proximity Read ↗

The human immunodeficiency virus-1 nef gene product: a positive factor for viral infection and replication in primary lymphocytes and macrophages.Semantic proximity Read ↗

Nef enhances human immunodeficiency virus type 1 infectivity and replication independently of viral coreceptor tropism.Semantic proximity Read ↗

Cell-dependent functional roles of HIV-1 Nef for virus replication (review).Semantic proximity Read ↗

Restoration of Wild-Type Infectivity to Human Immunodeficiency Virus Type 1 Strains Lacking nef by Intravirion Reverse TranscriptionSemantic proximity Read ↗

Dissociation of the CD4 downregulation and viral infectivity enhancement functions of human immunodeficiency virus type 1 NefSemantic proximity Read ↗

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