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HIV-1 Nef Enhances Both Membrane Expression and Virion Incorporation of Env Products

1 May 2004

Abstract excerpt

The expression of human immunodeficiency virus Nef increases the viral infectivity through mechanisms still not fully elucidated. Here we report that wild-type (wt) human immunodeficiency virus, type 1 (HIV-1), particles were neutralized by higher concentrations of either anti-Env glycoprotein (gp) 41 antibodies or recombinant soluble human CD4 compared with Deltanef HIV-1. This appeared to be the result of a...

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PMID: 15033985
DOI: 10.1074/jbc.m312453200

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HIV-1 Nef Enhances Both Membrane Expression and Virion Incorporation of Env ProductsPMID 15033985Read ↗

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