Article
Human immunodeficiency virus type 1 Nef protein is incorporated into virus particles and specifically cleaved by the viral proteinase.
Virology - 1 May 1996
Welker R, Kottler H, Kalbitzer H R, Kräusslich H G
Abstract excerpt
The Nef protein of primate immunodeficiency viruses is essential for establishing a highly productive pathogenic infection in vivo. In tissue culture, Nef is not required for infection but enhances viral infectivity. This effect is most pronounced in unstimulated primary lymphocytes and occurs in...
Topics
- Animals
- Cell Line
- Cell Line, Transformed
- Chlorocebus aethiops
- Gene Products, nef
- HIV Protease
- HIV-1
- Humans
- Mutation
- Substrate Specificity
- Transfection
- Viral Proteins
- Virion
- Virus Assembly
- nef Gene Products, Human Immunodeficiency Virus