Article
Cytotoxic activity of rev protein of human immunodeficiency virus type 1 by nucleolar dysfunction.
Experimental cell research - 1 Nov 1993
Nosaka T, Takamatsu T, Miyazaki Y, Sano K, Sato A, Kubota S, Sakurai M, Ariumi Y, Nakai M, Fujita S
Abstract excerpt
The rev protein (Rev) of the human immunodeficiency virus type 1 (HIV-1) is known as a post-transcriptional regulator of viral gene expression. It is located in the cell nucleolus. Transiently expressed Rev caused nucleolar ballooning and deformity with aberrant accumulation of rRNAs, and de novo synthesis of rRNAs decreased dramatically in these cells. However, similarly expressed rex protein (Rex) of the human...
Topics
- Base Sequence
- Blotting, Western
- Cell Death
- Cell Line
- Cell Nucleolus
- Cytopathogenic Effect, Viral
- Fluorescent Antibody Technique
- Gene Products, rev
- Gene Products, rex
- HIV-1
- Humans