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Article

Characterization of two independent amino acid substitutions that disrupt the DNA repair functions of the yeast Apn1.

Biochemistry - 3 Jun 2003

Jilani Arshad, Vongsamphanh Ratsavarinh, Leduc Anick, Gros Laurent, Saparbaev Murat, Ramotar Dindial

Abstract excerpt

The members of the Endo IV family of DNA repair enzymes, including Saccharomyces cerevisiae Apn1 and Escherichia coli endonuclease IV, possess the capacity to cleave abasic sites and to remove 3'-blocking groups at single-strand breaks via apurinic/apyrimidinic (AP) endonuclease and 3'-diesterase activities, respectively. In addition, Endo IV family members are able to recognize and incise oxidative base damages...

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Identifiers

PMID: 12767225
DOI: 10.1021/bi034163m

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Characterization of two independent amino acid substitutions that disrupt the DNA repair functions of the yeast Apn1.PMID 12767225Read ↗

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