Article

The activity of yeast Apn2 AP endonuclease at uracil-derived AP sites is dependent on the major carbon source

2020-09-02

Abstract excerpt

<h4>ABSTRACT</h4> Yeast Apn2 is an AP endonuclease and DNA 3’-diesterase that belongs to the Exo III family with homology to the E. coli exonuclease III, Schizosaccharomyces pombe eth1, and human AP endonucleases APEX1 and APEX2. In the absence of Apn1, the major AP endonuclease in yeast, Apn2 can cleave the DNA backbone at an AP lesion initiating the base excision repair pathway. In order to study the role and...

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Literature Corpus work: fec94c39-1fbc-5512-af27-0a80d74f8e69
DOI: 10.1101/2020.09.01.278135

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