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Article

Pir1p mediates translocation of the yeast Apn1p endonuclease into the mitochondria to maintain genomic stability.

Molecular and cellular biology - 1 Mar 2001

Vongsamphanh R, Fortier P K, Ramotar D

Abstract excerpt

The mitochondrial genome is continuously subject to attack by reactive oxygen species generated through aerobic metabolism. This leads to the formation of a variety of highly genotoxic DNA lesions, including abasic sites. Yeast Apn1p is localized to the nucleus, where it functions to cleave abasi...

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Identifiers

PMID: 11238901
DOI: 10.1128/MCB.21.5.1647-1655.2001
PMCID: PMC86710

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-11238901-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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