Article
The largest variant of platelet glycoprotein Ib alpha has four tandem repeats of 13 amino acids in the macroglycopeptide region and a genetic linkage with methionine145.
Blood - 15 Aug 1995
Ishida F, Furihata K, Ishida K, Yan J, Kitano K, Kiyosawa K, Furuta S
Abstract excerpt
Platelet membrane glycoprotein Ib alpha (GPIb alpha) bears the human platelet alloantigen (HPA)-2 and molecular weight (MW) polymorphisms on sodium dodecyl sulfate-polyacrylamide gels. HPA-2 arises from a threonine/methionine dimorphism at residue 145 of the GPIb alpha sequence, whereas different...
Topics
- Alleles
- Base Sequence
- Biological Evolution
- DNA Primers
- Female
- Humans
- Isoantigens
- Male
- Methionine
- Molecular Sequence Data
- Molecular Weight
- Pedigree
- Platelet Membrane Glycoproteins
- Polymorphism, Genetic
- Repetitive Sequences, Nucleic Acid
- Sequence Alignment
- Sequence Homology, Amino Acid