The GPIa C807T dimorphism associated with platelet collagen receptor density is not a risk factor for myocardial infarction.

doi:10.1046/j.1365-2141.1999.01597.x

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Article

The GPIa C807T dimorphism associated with platelet collagen receptor density is not a risk factor for myocardial infarction.

British journal of haematology - 1 Sept 1999

Croft S A, Hampton K K, Sorrell J A, Steeds R P, Channer K S, Samani N J, Daly M E

Abstract excerpt

The platelet collagen receptor, GPIa/IIa, is an important mediator of platelet adhesion to fibrillar collagens at sites of vascular injury. Recently, a dimorphism at nucleotide 807 of the GPIa cDNA (TTC/TTT in codon 224) was shown to be associated with variation in GPIa/IIa receptor density on the platelet surface. We conducted a case-control study to determine if the 807T allele, linked with increased GPIa/IIa...

Topics

Adult
Aged
Alleles
Cohort Studies
Female
Genotype
Humans
Integrins
Male
Middle Aged
Myocardial Infarction
Receptors, Collagen
Risk Factors

Source

Open in PubMed

Identifiers

PMID: 10468872
DOI: 10.1046/j.1365-2141.1999.01597.x

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