Human TCR alpha/beta+ CD4-CD8- double-negative T cells in patients with autoimmune lymphoproliferative syndrome express restricted Vbeta TCR diversity and are clonally related to CD8+ T cells.

doi:10.4049/jimmunol.181.1.440

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Article

Human TCR alpha/beta+ CD4-CD8- double-negative T cells in patients with autoimmune lymphoproliferative syndrome express restricted Vbeta TCR diversity and are clonally related to CD8+ T cells.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jul 2008

Bristeau-Leprince Anne, Mateo Véronique, Lim Annick, Magerus-Chatinet Aude, Solary Eric, Fischer Alain, Rieux-Laucat Frédéric, Gougeon Marie-Lise

Abstract excerpt

The peripheral expansion of alpha/beta+-CD4-CD8- double negative (DN) T cells in patients with autoimmune lymphoproliferative syndrome (ALPS) is a consistent feature of this disease, and part of the diagnostic criteria of ALPS. The origin of these cells remains undetermined. They could derive from mature T cells that have lost coreceptor expression, or represent a special minor cell lineage. To investigate...

Topics

Adult
Amino Acid Sequence
Autoantigens
Autoimmune Diseases
Base Sequence
CD4 Antigens
CD8 Antigens
Cell Separation
Child
Child, Preschool

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Female

Humans

Infant

Lymphoproliferative Disorders

Male

Molecular Sequence Data

Phenotype

Receptors, Antigen, T-Cell, alpha-beta

Source

Open in PubMed

Identifiers

PMID: 18566410
DOI: 10.4049/jimmunol.181.1.440

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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