Differential activation of the nuclear factor-kappa B by TNF muteins specific for the p60 and p80 TNF receptors.

Abstract excerpt

Human TNF is a highly pleiotropic cytokine that mediates its effects by binding to two distinct receptors, viz p60 and p80, which transmit their signals independently of each other. Activation of the transcription factor NF-kappa B is one of the earliest events induced by TNF, but whether it is mediated through one or both forms of the TNF receptor is controversial. in the present studies, we examined the role of...

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