Article
TNF-alpha, the great imitator: role of p55 and p75 TNF receptors in hematopoiesis.
Stem cells (Dayton, Ohio) - 1 Jan 1994
Jacobsen S E, Jacobsen F W, Fahlman C, Rusten L S
Abstract excerpt
The clinical application of tumor necrosis factor-alpha (TNF-alpha) has so far been limited due to the severe adverse effects associated with its systemic use. Recently, two distinct TNF receptors with molecular weights of 55 kDa (TNFR55) and 75 kDa (TNFR75) have been cloned and characterized. The subsequent development of TNF-alpha mutants with selective activity on either TNFR55 or TNFR75 suggest that such...
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