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Article

Tropomyosin isoforms regulate cofilin 1 activity by modulating actin filament conformation.

Archives of biochemistry and biophysics - 30 Mar 2020

Ostrowska-Podhorodecka Zofia, Śliwinska Małgorzata, Reisler Emil, Moraczewska Joanna

Abstract excerpt

Tropomyosin and cofilin are involved in the regulation of actin filament dynamic polymerization and depolymerization. Binding of cofilin changes actin filaments structure, leading to their severing and depolymerization. Non-muscle tropomyosin isoforms were shown before to differentially regulate the activity of cofilin 1; products of TPM1 gene stabilized actin filaments, but products of TPM3 gene promoted...

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Identifiers

PMID: 31996302
DOI: 10.1016/j.abb.2020.108280
PMCID: PMC7291848

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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