Article
Hepatitis C virus variants circumventing cytotoxic T lymphocyte activity as a mechanism of chronicity.
Gastroenterology - 1 Oct 1998
Tsai S L, Chen Y M, Chen M H, Huang C Y, Sheen I S, Yeh C T, Huang J H, Kuo G C, Liaw Y F
Abstract excerpt
BACKGROUND & AIMS: High rate of chronicity after acute hepatitis C virus (HCV) infection cannot be explained in the presence of a multispecific cytotoxic T lymphocyte (CTL) response. The aim of this study was to investigate the effect of virus variants on CTL activity in patients in whom chronici...
Topics
- Acute Disease
- Adult
- Amino Acid Sequence
- Base Sequence
- Cell Line
- Female
- Genetic Variation
- HLA-A2 Antigen
- Hepacivirus
- Hepatitis C, Chronic
- Humans
- Immunoglobulin Variable Region
- Male
- Middle Aged
- Molecular Sequence Data
- Peptide Fragments
- Receptors, Antigen, T-Cell, alpha-beta
- T-Lymphocytes, Cytotoxic