Article
Parathyroid hormone receptor signalling in osterix-expressing mesenchymal progenitors is essential for tooth root formation.
Nature communications - 12 Apr 2016
Ono Wanida, Sakagami Naoko, Nishimori Shigeki, Ono Noriaki, Kronenberg Henry M
Abstract excerpt
Dental root formation is a dynamic process in which mesenchymal cells migrate toward the site of the future root, differentiate and secrete dentin and cementum. However, the identities of dental mesenchymal progenitors are largely unknown. Here we show that cells expressing osterix are mesenchymal progenitors contributing to all relevant cell types during morphogenesis. The majority of cells expressing...
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