Article
Trans-chromosomal recombination within the Ig heavy chain switch region in B lymphocytes.
Proceedings of the National Academy of Sciences of the United States of America - 29 Sept 1998
Kingzette M, Spieker-Polet H, Yam P C, Zhai S K, Knight K L
Abstract excerpt
Somatic DNA rearrangements in B lymphocytes, including V(D)J gene rearrangements and isotype switching, generally occur in cis, i. e., intrachromosomally. We showed previously, however, that 3 to 7% of IgA heavy chains have the VH and Calpha regions encoded in trans. To determine whether the tran...
Topics
- Alleles
- Animals
- B-Lymphocytes
- Base Sequence
- Cloning, Molecular
- DNA Primers
- DNA, Complementary
- Gene Expression
- Gene Rearrangement, B-Lymphocyte, Heavy Chain
- Genes, Immunoglobulin
- Hybridomas