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Article

Trans-chromosomal recombination within the Ig heavy chain switch region in B lymphocytes.

Proceedings of the National Academy of Sciences of the United States of America - 29 Sept 1998

Kingzette M, Spieker-Polet H, Yam P C, Zhai S K, Knight K L

Abstract excerpt

Somatic DNA rearrangements in B lymphocytes, including V(D)J gene rearrangements and isotype switching, generally occur in cis, i. e., intrachromosomally. We showed previously, however, that 3 to 7% of IgA heavy chains have the VH and Calpha regions encoded in trans. To determine whether the trans-association of VH and Calpha occurred by trans-chromosomal recombination, by trans-splicing, or by trans-chromosomal...

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Identifiers

PMID: 9751752
DOI: 10.1073/pnas.95.20.11840
PMCID: PMC21727

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