Article
Accumulation of splenic B1a cells with potent antigen-presenting capability in NZM2410 lupus-prone mice.
Arthritis and rheumatism - 1 Sept 1998
Mohan C, Morel L, Yang P, Wakeland E K
Abstract excerpt
OBJECTIVE: In order to shed light on the role of splenic B1 cells in disease pathogenesis in lupus-prone mice, this study was undertaken to determine how efficiently these cells can serve as antigen-presenting cells (APC) and to ascertain which murine lupus susceptibility loci dictate the expansi...
Topics
- Animals
- Antigen-Presenting Cells
- Antigens, Surface
- B-Lymphocytes
- Cell Count
- Female
- Flow Cytometry
- Immunoenzyme Techniques
- Lupus Erythematosus, Systemic
- Lymphocyte Activation
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Inbred NZB
- Mice, Mutant Strains
- Peritoneal Cavity
- Phenotype
- Spleen