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Article

B Cell–Intrinsic CD84 and Ly108 Maintain Germinal Center B Cell Tolerance

24 Mar 2015

Abstract excerpt

Signaling lymphocyte activation molecules (SLAMs) play an integral role in immune regulation. Polymorphisms in the SLAM family receptors are implicated in human and mouse model of lupus disease. The lupus-associated, somatically mutated, and class-switched pathogenic autoantibodies are generated in spontaneously developed germinal centers (GCs) in secondary lymphoid organs. The role and mechanism of B...

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PMID: 25801429
DOI: 10.4049/jimmunol.1403023

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