Regulation of Escherichia coli secA by cellular protein secretion proficiency requires an intact gene X signal sequence and an active translocon.

Abstract excerpt

secA is translationally regulated by the protein secretion proficiency state of the Escherichia coli cell. This regulation was explored by making signal sequence mutations in the gene upstream of secA, gene X, which promotes secA translational coupling. Gene X signal sequence mutants were constit...

Topics

• Adenosine Triphosphatases
• Bacterial Proteins
• Chromosomes, Bacterial
• Escherichia coli
• Escherichia coli Proteins
• Gene Expression Regulation, Bacterial
• Membrane Transport Proteins
• Mutation
• Plasmids
• Protein Sorting Signals
• SEC Translocation Channels
• SecA Proteins