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Article

Targeting of signal sequenceless proteins for export in Escherichia coli with altered protein translocase.

The EMBO journal - 1 Oct 1996

Prinz W A, Spiess C, Ehrmann M, Schierle C, Beckwith J

Abstract excerpt

Most extracytoplasmic proteins are synthesized with an N-terminal signal sequence that targets them to the export apparatus. Escherichia coli prlA mutants (altered in the secY gene) are able to export cell envelope proteins lacking any signal sequence. In order to understand how such proteins are targeted for export, we isolated mutations in a signal sequenceless version of alkaline phosphatase that block its...

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Identifiers

PMID: 8895566
PMCID: PMC452265

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Research trail→

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Targeting of signal sequenceless proteins for export in Escherichia coli with altered protein translocase.PMID 8895566Read ↗

A signal sequence is not required for protein export in prlA mutants of Escherichia coli.Semantic proximity Read ↗

Defective translocation of a signal sequence mutant in a prlA4 suppressor strain of Escherichia coli.Semantic proximity Read ↗

Structure, function, and biogenesis of SecY, an integral membrane protein involved in protein export.Semantic proximity Read ↗

SecY variants that interfere with Escherichia coli protein export in the presence of normal secY.Semantic proximity Read ↗

An amino-terminal secretion signal is required for YplA export by the Ysa, Ysc, and flagellar type III secretion systems of Yersinia enterocolitica biovar 1B.Semantic proximity Read ↗

Recognition of secretory proteins in Escherichia coli requires signals in addition to the signal sequence and slow folding.Semantic proximity Read ↗

Both transmembrane domains of SecG contribute to signal sequence recognition by the Escherichia coli protein export machinery.Semantic proximity Read ↗

Characterization of cold-sensitive secY mutants of Escherichia coli.Semantic proximity Read ↗

Arginine 357 of SecY is needed for SecA-dependent initiation of preprotein translocation.Semantic proximity Read ↗

Novel prlA alleles defective in supporting staphylokinase processing in Escherichia coli.Semantic proximity Read ↗

A positive residue in the hydrophobic core of the Escherichia coli lipoprotein signal peptide suppresses the secretion defect caused by an acidic amino terminus.Semantic proximity Read ↗

The PrlA and PrlG phenotypes are caused by a loosened association among the translocase SecYEG subunits.Semantic proximity Read ↗

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