Article
Cloning and characterization of the 5'-flanking region for the human topoisomerase III gene.
The Journal of biological chemistry - 2 Oct 1998
Kim J C, Yoon J B, Koo H S, Chung I K
Abstract excerpt
The human DNA topoisomerase III (hTOP3) gene encodes a topoisomerase homologous to the Escherichia coli DNA topoisomerase I subfamily. To understand the mechanisms responsible for regulating hTOP3 expression, we have cloned the 5'-flanking region of the gene coding for the hTOP3 and analyzed its...
Topics
- Base Sequence
- Binding Sites
- Cloning, Molecular
- DNA Mutational Analysis
- DNA Topoisomerases, Type I
- DNA-Binding Proteins
- Erythroid-Specific DNA-Binding Factors
- Gene Expression Regulation
- Genes, Reporter
- HeLa Cells
- Humans
- Molecular Sequence Data
- Mutation
- Nuclear Proteins
- Podophyllin
- Podophyllotoxin
- Promoter Regions, Genetic
- RNA, Messenger