Article
An unusually compact external promoter for RNA polymerase III transcription of the human H1RNA gene.
Nucleic acids research - 15 Jun 2001
Myslinski E, Amé J C, Krol A, Carbon P
Abstract excerpt
H1 RNA, the RNA component of the human nuclear RNase P, is encoded by a unique gene transcribed by RNA polymerase III (Pol III). In this work, cis-acting elements and trans-acting factors involved in human H1 gene transcription were characterized by transcription assays of mutant templates and DNA binding assays of recombinant proteins. Four elements, lying within 100 bp of 5'-flanking sequences, were defined to...
Topics
- Animals
- Base Sequence
- Binding Sites
- COS Cells
- DNA-Binding Proteins
- Endoribonucleases
- Genes, Reporter
- Humans
- Mice
- Molecular Sequence Data
- Mutation
- Oocytes
- Promoter Regions, Genetic
- Protein Structure, Tertiary