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Article

Sp1 and Sp3 control constitutive expression of the human NHE2 promoter by interactions with the proximal promoter and the transcription initiation site.

The Biochemical journal - 1 Oct 2007

Pearse Ian, Zhu Ying X, Murray Eleanor J, Dudeja Pradeep K, Ramaswamy Krishnamurthy, Malakooti Jaleh

Abstract excerpt

We have previously cloned the human Na+/H+ exchanger NHE2 gene and its promoter region. In the present study, the regulatory elements responsible for the constitutive expression of NHE2 were studied. Transient transfection assays revealed that the -40/+150 promoter region contains the core promoter responsible for the optimal promoter activity. A smaller fragment, -10/+40, containing the TIS (transcription...

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Identifiers

PMID: 17561809
DOI: 10.1042/BJ20070364
PMCID: PMC2267401

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