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Article

Cell type-dependent regulation of human DNA topoisomerase III alpha gene expression by upstream stimulatory factor 2.

FEBS letters - 7 Sept 2001

Han S Y, Kim J C, Suh J M, Chung I K

Abstract excerpt

Here, we report that an E-box element located within the human topoisomerase III alpha (hTOP3 alpha) gene promoter acts as a cell type-specific enhancer. The upstream stimulatory factor (USF) was shown to specifically recognize the mutationally sensitive E-box element. When assayed by transient transfection with hTOP3 alpha promoter-dependent reporter genes, USF is transcriptionally active in HeLa cells but lacks...

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Share to DNA Topoisomerases, Type I
Share to Enhancer Elements, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Genes, Reporter

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Share to Regulatory Sequences, Nucleic Acid

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Source

Identifiers

PMID: 11557042
DOI: 10.1016/s0014-5793(01)02777-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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