Article
Tyrosine dephosphorylated cortactin downregulates contractility at the epithelial zonula adherens through SRGAP1.
Nature communications - 5 Oct 2017
Liang Xuan, Budnar Srikanth, Gupta Shafali, Verma Suzie, Han Siew-Ping, Hill Michelle M, Daly Roger J, Parton Robert G, Hamilton Nicholas A, Gomez Guillermo A, Yap Alpha S
Abstract excerpt
Contractile adherens junctions support cell-cell adhesion, epithelial integrity, and morphogenesis. Much effort has been devoted to understanding how contractility is established; however, less is known about whether contractility can be actively downregulated at junctions nor what function this might serve. We now identify such an inhibitory pathway that is mediated by the cytoskeletal scaffold, cortactin....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.