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Article

Cortactin deficiency is associated with reduced neutrophil recruitment but increased vascular permeability in vivo.

The Journal of experimental medicine - 1 Aug 2011

Schnoor Michael, Lai Frank P L, Zarbock Alexander, Kläver Ruth, Polaschegg Christian, Schulte Dörte, Weich Herbert A, Oelkers J Margit, Rottner Klemens, Vestweber Dietmar

Abstract excerpt

Neutrophil extravasation and the regulation of vascular permeability require dynamic actin rearrangements in the endothelium. In this study, we analyzed in vivo whether these processes require the function of the actin nucleation-promoting factor cortactin. Basal vascular permeability for high molecular weight substances was enhanced in cortactin-deficient mice. Despite this leakiness, neutrophil extravasation in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21788407
DOI: 10.1084/jem.20101920
PMCID: PMC3149227

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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