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Article

Quantitative trait loci for blood glucose confirm diabetes predisposing and protective genes, Iddm4 and Iddm5r, in the spontaneously diabetic BB/OK rat.

International journal of molecular medicine - 1 Nov 1998

Klöting I, Van Den Brandt J, Kovács P

Abstract excerpt

Several crossing studies using diabetic BB/OK and diabetes-resistant rat strains have clearly shown that the MHC class-II-genes of the RT1u haplotype (Iddm1) and the lymphopenia (Iddm2) are essential but not sufficient for type 1 diabetes development. The search for additional diabetogenic genes revealed predisposing non-MHC genes, Iddm3 and Iddm4, and a diabetes protective gene, Iddm5r, cosegregating with...

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Identifiers

PMID: 9858659
DOI: 10.3892/ijmm.2.5.597

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Research trail→

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Quantitative trait loci for blood glucose confirm diabetes predisposing and protective genes, Iddm4 and Iddm5r, in the spontaneously diabetic BB/OK rat.PMID 9858659Read ↗

Mapping of novel genes predisposing or protecting diabetes development in the BB/OK rat.Semantic proximity Read ↗

Crosses between diabetic BB/OK and wild rats confirm that a third gene is essential for diabetes development.Semantic proximity Read ↗

Locus on chromosome 18 cosegregates with diabetes in the BB/OK rat subline.Semantic proximity Read ↗

Genes of the immune system cosegregate with the age at onset of diabetes in the BB/OK rat.Semantic proximity Read ↗

Alleles of diabetes-resistant BN rats contribute to insulin-dependent type 1 diabetes mellitus.Semantic proximity Read ↗

Genetic variation in the multifunctional transcription factor Yy1 and type 1 diabetes mellitus in the BB rat.Semantic proximity Read ↗

A novel susceptibility locus on rat chromosome 8 affects spontaneous but not experimentally induced type 1 diabetes.Semantic proximity Read ↗

Type 1 Diabetes in the BB Rat: A Polygenic DiseaseSemantic proximity Read ↗

BB rat diabetes susceptibility and body weight regulation genes colocalize on chromosome 2.Semantic proximity Read ↗

Phenotypic differences between diabetes-prone BB rat sublines cosegregate with loci on chromosomes X and 10.Semantic proximity Read ↗

Diabetes-prone and diabetes-resistant BB rats share a common major diabetes susceptibility locus, iddm4: additional evidence for a "universal autoimmunity locus" on rat chromosome 4.Semantic proximity Read ↗

Diabetes segregates as a single locus in crosses between inbred BB rats prone or resistant to diabetes.Semantic proximity Read ↗

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