Article
Quantitative trait loci for blood glucose confirm diabetes predisposing and protective genes, Iddm4 and Iddm5r, in the spontaneously diabetic BB/OK rat.
International journal of molecular medicine - 1 Nov 1998
Klöting I, Van Den Brandt J, Kovács P
Abstract excerpt
Several crossing studies using diabetic BB/OK and diabetes-resistant rat strains have clearly shown that the MHC class-II-genes of the RT1u haplotype (Iddm1) and the lymphopenia (Iddm2) are essential but not sufficient for type 1 diabetes development. The search for additional diabetogenic genes...
Topics
- Animals
- Blood Glucose
- Chromosomes, Mammalian
- Diabetes Mellitus, Type 1
- Female
- Genetic Linkage
- Genetic Predisposition to Disease
- Humans
- Lod Score
- Male
- Membrane Proteins
- Microsatellite Repeats
- Quantitative Trait Loci
- Rats
- Rats, Inbred BB