Article
Genetic variation in the multifunctional transcription factor Yy1 and type 1 diabetes mellitus in the BB rat.
Molecular genetics and metabolism - 1 Jul 2004
Klöting Nora, Klöting Ingrid
Abstract excerpt
Spontaneous diabetes in B(io)B(reeding) rats is complex, polygenic, and recessively inherited. Several crossing studies have demonstrated that beside the class II genes of the major histocompatibility complex (MHC, Iddm1) additional non-MHC genes are involved in diabetes development. One of them, Iddm4, was initially mapped on chromosome 6q32. To study the physiologic importance of Iddm4 a congenic BB.SHR rat...
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