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Article

Locus on chromosome 18 cosegregates with diabetes in the BB/OK rat subline.

Diabete & metabolisme - 1 Dec 1995

Klöting I, Vogt L, Serikawa T

Abstract excerpt

The spontaneously diabetic BB rat is a well-established animal model of human insulin-dependent diabetes mellitus. Besides the lymphopenia gene (Iddm 1) and the MHC class-II genes of the RT1u haplotype (Iddm 2), at least one other non-MHC gene (Iddm 3) is considered essential for diabetes development. To investigate the participation of this third gene in the development of diabetes in our BB/OK rat subline, we...

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PMID: 8586150

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Locus on chromosome 18 cosegregates with diabetes in the BB/OK rat subline.PMID 8586150Read ↗

Mapping of novel genes predisposing or protecting diabetes development in the BB/OK rat.Semantic proximity Read ↗

Quantitative trait loci for blood glucose confirm diabetes predisposing and protective genes, Iddm4 and Iddm5r, in the spontaneously diabetic BB/OK rat.Semantic proximity Read ↗

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Alleles of diabetes-resistant BN rats contribute to insulin-dependent type 1 diabetes mellitus.Semantic proximity Read ↗

Phenotypic differences between diabetes-prone BB rat sublines cosegregate with loci on chromosomes X and 10.Semantic proximity Read ↗

Genetic variation in the multifunctional transcription factor Yy1 and type 1 diabetes mellitus in the BB rat.Semantic proximity Read ↗

Genes of the immune system cosegregate with the age at onset of diabetes in the BB/OK rat.Semantic proximity Read ↗

A novel susceptibility locus on rat chromosome 8 affects spontaneous but not experimentally induced type 1 diabetes.Semantic proximity Read ↗

BB rat diabetes susceptibility and body weight regulation genes colocalize on chromosome 2.Semantic proximity Read ↗

Diabetes segregates as a single locus in crosses between inbred BB rats prone or resistant to diabetes.Semantic proximity Read ↗

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Suggestive evidence for association of human chromosome 18q12-q21 and its orthologue on rat and mouse chromosome 18 with several autoimmune diseases.Semantic proximity Read ↗

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