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Article

Phenotypic differences between diabetes-prone BB rat sublines cosegregate with loci on chromosomes X and 10.

Biochemistry and molecular biology international - 1 Aug 1998

Klöting I, Kovacs P

Abstract excerpt

BB rat sublines, all developing an insulin-dependent diabetes, differ in several phenotypic traits and in the genotype. To study the genetic basis of phenotypic differences diabetic BB/OK and BB/Mol rats characterized by significantly different frequency and age at onset of diabetes were reciprocally crossed. F1 females of both crosses were backcrossed onto diabetic BB/Mol rats resulting 94 BC1 hybrids which were...

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Identifiers

PMID: 9739450
DOI: 10.1002/iub.7510450503

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Phenotypic differences between diabetes-prone BB rat sublines cosegregate with loci on chromosomes X and 10.PMID 9739450Read ↗

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Genes of the immune system cosegregate with the age at onset of diabetes in the BB/OK rat.Semantic proximity Read ↗

Alleles of diabetes-resistant BN rats contribute to insulin-dependent type 1 diabetes mellitus.Semantic proximity Read ↗

Crosses between diabetic BB/OK and wild rats confirm that a third gene is essential for diabetes development.Semantic proximity Read ↗

Locus on chromosome 18 cosegregates with diabetes in the BB/OK rat subline.Semantic proximity Read ↗

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Model-based prediction of diabetes incidence in BB/OK rats.Semantic proximity Read ↗

Diabetes segregates as a single locus in crosses between inbred BB rats prone or resistant to diabetes.Semantic proximity Read ↗

BB rat diabetes susceptibility and body weight regulation genes colocalize on chromosome 2.Semantic proximity Read ↗

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