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Article

Diabetes segregates as a single locus in crosses between inbred BB rats prone or resistant to diabetes.

The Journal of experimental medicine - 1 Jul 1991

Markholst H, Eastman S, Wilson D, Andreasen B E, Lernmark A

Abstract excerpt

Diabetes-prone (DP) BB rats spontaneously develop insulin-dependent diabetes resembling type 1 diabetes mellitus in man. They also exhibit lifelong T cell deficiency. The segregation of both diabetes and lymphopenia was studied in crosses between this inbred line of rats and the related but nondiabetic and nonlymphopenic inbred diabetes-resistant (DR) BB rat line. Diabetes segregated as a single, autosomal...

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Identifiers

PMID: 2056281
DOI: 10.1084/jem.174.1.297
PMCID: PMC2118894

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Diabetes segregates as a single locus in crosses between inbred BB rats prone or resistant to diabetes.PMID 2056281Read ↗

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Mapping of novel genes predisposing or protecting diabetes development in the BB/OK rat.Semantic proximity Read ↗

Quantitative trait loci for blood glucose confirm diabetes predisposing and protective genes, Iddm4 and Iddm5r, in the spontaneously diabetic BB/OK rat.Semantic proximity Read ↗

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