Diabetes segregates as a single locus in crosses between inbred BB rats prone or resistant to diabetes.

doi:10.1084/jem.174.1.297

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Article

Diabetes segregates as a single locus in crosses between inbred BB rats prone or resistant to diabetes.

The Journal of experimental medicine - 1 Jul 1991

Markholst H, Eastman S, Wilson D, Andreasen B E, Lernmark A

Abstract excerpt

Diabetes-prone (DP) BB rats spontaneously develop insulin-dependent diabetes resembling type 1 diabetes mellitus in man. They also exhibit lifelong T cell deficiency. The segregation of both diabetes and lymphopenia was studied in crosses between this inbred line of rats and the related but nondi...

Topics

Aging
Animals
Chromosome Mapping
Crosses, Genetic
Diabetes Mellitus, Experimental
Female
Genetic Predisposition to Disease
Hybridization, Genetic
Immunity, Innate
Islets of Langerhans
Male
Rats
Rats, Inbred BB

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